Clinical Snapshot

Clinical Grade “SNaPshot” Genetic Mutation Profiling in Multiple Myeloma

Whole genome sequencing studies have identified several oncogenic mutations in multiple myeloma (MM). As MM progresses, it evolves genetically underscoring the need to have tools for rapid detection of targetable mutations to optimize individualized treatment. Massachusetts General Hospital (MGH) has developed a Clinical Laboratory Improvement Amendments (CLIA)-approved, high-throughput, genoty...

2014 Rural Clinical School Training and Support Program Snapshot survey.

INTRODUCTION The Rural Clinical Training and Support (RCTS) program is an Australian Government initiative to address the shortage of medical practitioners within rural and remote Australia. There is a large amount of published information about the RCTS program and rural medical student cohorts who have undertaken short- and long-term rotations. However, very little is known about the academic...

SnapShot: melanoma.

SnapShot: Macroautophagy

(Middle) Cellular Events in Macroautophagy Macroautophagy (hereafter referred to as autophagy) is a catabolic process in which portions of the cytoplasm are sequestered within double-or multimembraned vesicles termed autophagosomes and then delivered to lysosomes for bulk degradation. The initial phases of macroautophagy consist of the formation of a phago-phore, which is also called an isolati...

SnapShot: Formins

See online version for legend and references. Autosomal-dominant nonsyndromic deafness (DFNA1), myeloproliferative defects, defects in T lymphocyte traffi cking and proliferation, tumor cell invasion, defects in natural killer lymphocyte function DIAPH2 (mDia3) Cdc42 Kinetochore Stable microtubule attachment to kinetochore for chromosome alignment Premature ovarian failure DIAPH3 (mDia2) Increa...